2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-153695
    TXA707
    TXA707, the active metabolite of TXA-709, is an FtsZ inhibitor with antibacterial activity. TXA707 is promising for research of S. aureus infections.
    TXA707
  • HY-124098
    Lignocaine N-oxide
    		99.86%
    Lignocaine N-oxide (Lidocaine N-oxide) is a compound derived from the metabolism of lidocaine. Lidocaine can be metabolized to its N-oxide in rat liver microsomes.
    Lignocaine N-oxide
  • HY-128379
    Labetalone hydrochloride
    		99.27%
    Labetalone hydrochloride is an impurity of Labetalol. Labetalol is an orally active adrenoceptor blocking agent which is a competitive antagonist at both alpha- and beta-adrenoceptor sites.
    Labetalone hydrochloride
  • HY-117580
    16α-Hydroxyprednisolone
    		99.73%
    16α-Hydroxyprednisolone is a stereoselective metabolite of the 22(R) epimer of the glucocorticoid budesonide via cytochrome P450 3A (CYP3A) enzymes.
    16α-Hydroxyprednisolone
  • HY-W042214
    Ritalinic acid
    		99.81%
    Ritalinic acid (Ritalinate) is the main inactive urinary metabolite of Methylphenidate. Methylphenidate has the potential for attention-deficit hyperactivity disorder and narcolepsy research.
    Ritalinic acid
  • HY-113483
    20-Carboxy-Leukotriene B4
    		≥98.0%
    20-Carboxy-Leukotriene B4 (20-COOH LTB4) is a metabolite of Leukotriene B4 (LTB4; HY-107608). 20-Carboxy-Leukotriene B4 binds to the BLT1 receptor with high affinity. 20-Carboxy-Leukotriene B4 inhibits LTB4-mediated neutrophil responses (migration, degranulation, leukotriene biosynthesis).
    20-Carboxy-Leukotriene B4
  • HY-131492
    Δ4-Dafachronic acid
    Δ4-Dafachronic acid is an agonist of DAF-12 and a metabolite of cholesterol.
    Δ4-Dafachronic acid
  • HY-W509381
    4-Hydroxyindole-3-acetic acid
    4-Hydroxyindole-3-acetic acid (4HIAA) is a metabolite of Psilocybin and Psilocin.
    4-Hydroxyindole-3-acetic acid
  • HY-133624
    1,1,3-Tribromoacetone
    		≥98.0%
    1,1,3-Tribromoacetone is an impurity of Methotrexate (HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis.
    1,1,3-Tribromoacetone
  • HY-126857S
    5-Hydroxy Omeprazole-d3
    		98.27%
    5-Hydroxy Omeprazole-d3 is deuterium labeled 5-Hydroxyomeprazole.
    5-Hydroxy Omeprazole-d<sub>3</sub>
  • HY-W019726
    Dehydro Nifedipine
    		99.84%
    Dehydro nifedipine (BAY-b 4759) is a metabolite of Nifedipine (HY-B0284). Nifedipine (BAY-a-1040) is a potent calcium channel blocker and an agent of choice for cardiac insufficiencies.
    Dehydro Nifedipine
  • HY-101671
    S-methyl-KE-298
    		≥98.0%
    S-methyl-KE-298 is an active metabolite of KE-298. KE-298 inhibits matrix metalloproteinase (MMP-1) production from rheumatoid arthritis (RA) synovial cells.
    S-methyl-KE-298
  • HY-12778
    Ivabradine metabolite N-Demethyl Ivabradine hydrochloride
    		99.63%
    N-Demethyl Ivabradine Hcl is a metabolite of Ivabradine, which is a specific inhibitor of the funny channel.
    Ivabradine metabolite N-Demethyl Ivabradine hydrochloride
  • HY-145453
    Propacetamol
    		Control 98.38%
    Propacetamol is an analgesic agent. Propacetamol also is a precursor form of paracetamol. Propacetamol can be used in postoperative pain, acute trauma and gastrointestinal disorders.
    Propacetamol
  • HY-138253R
    2′,2′-Difluorodeoxyuridine (Standard)
    2′,2′-Difluorodeoxyuridine (Standard) is the analytical standard of 2′,2′-Difluorodeoxyuridine. This product is intended for research and analytical applications. 2′,2′-Difluorodeoxyuridine (dFdU) is the main metabolite of Gemcitabine (HY-17026). 2′,2′-Difluorodeoxyuridine causes a concentration- and schedule- dependent radiosensitising effect in vitro.
    2′,2′-Difluorodeoxyuridine (Standard)
  • HY-126303
    GS-443902
    		99.87%
    GS-443902 (GS-441524 triphosphate) is a potent viral RNA-dependent RNA-polymerases (RdRp) inhibitor with IC50s of 1.1 µM, 5 µM for RSV RdRp and HCV RdRp, respectively. GS-443902 is the active triphosphate metabolite of Remdesivir.
    GS-443902
  • HY-148375
    Abiraterone sulfate
    		98.87%
    Abiraterone sulfate is a metabolite of Abiraterone (HY-148377). Abiraterone is a potent and irreversible CYP17A1 inhibitor with antiandrogen activity.
    Abiraterone sulfate
  • HY-138627
    AST5902
    AST5902 is the active metabolite of Firmonertinib (HY-112870) (EGFR inhibitor). AST5902 has antineoplastic activity.
    AST5902
  • HY-135391S
    Ezetimibe phenoxy glucuronide-d4
    Ezetimibe phenoxy glucuronide-d4 is the deuterium labeled Ezetimibe phenoxy glucuronide. Ezetimibe phenoxy glucuronide is the active metabolite of Ezetimibe. Antihyperlipoproteinemic activity[1]. Ezetimibe is a potent cholesterol absorption inhibitor[2].
    Ezetimibe phenoxy glucuronide-d<sub>4</sub>
  • HY-131267
    Febuxostat sec-butoxy acid
    Febuxostat sec-butoxy acid is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a Ki of 0.6 nM.
    Febuxostat sec-butoxy acid
Cat. No. Product Name / Synonyms Application Reactivity