2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W103882
    2-(Benzhydrylsulfinyl)acetic acid
    		≥99.0%
    2-Benzhydrylsulfinylacetic acid (Modafinil acid) is the metabolite of modafinil.
    2-(Benzhydrylsulfinyl)acetic acid
  • HY-G0001A
    Lurasidone Metabolite 14283 hydrochloride
    		99.06%
    Lurasidone Metabolite 14283 hydrochloride is a major active metabolite of Lurasidone. Lurasidone is a FDA approved agent for the treatment of schizophrenia.
    Lurasidone Metabolite 14283 hydrochloride
  • HY-12770
    Mebeverine alcohol
    		99.61%
    Mebeverine alcohol is a metabolite of Mebeverine, which is a musculotropic antispasmodic drug.
    Mebeverine alcohol
  • HY-136560
    6-Azathymine acid
    6-Azathymine acid is a metabolite of Pymetrozine. Pymetrozine is active against plant-sucking insects, such as aphids and whiteflies in vegetables, cotton, field crops and fruits and affects the nervous regulation of feeding behavior.
    6-Azathymine acid
  • HY-118099
    Florfenicol amine hydrochloride
    		99.45%
    Florfenicol amine hydrochloride is a metabolite of Florfenicol (HY-B1374). Florfenicol inhibits bacterial protein synthesis by binding to 50S and 70S subunits in the ribosome to abolish the activity of peptidyltransferase. Florfenicol, is a veterinary antibiotic, can be used in aquaculture to control susceptible bacterial diseases.
    Florfenicol amine hydrochloride
  • HY-B0794A
    AZ7550 hydrochloride
    		98.66%
    AZ7550 hydrochloride is an active metabolite of AZD9291 and inhibits the activity of IGF1R with an IC50 of 1.6 μM.
    AZ7550 hydrochloride
  • HY-N10322
    2-Hydroxyemodin
    		99.74%
    2-Hydroxyemodin is an active metabolite of emodin in the hepatic microsomes. Emodin is an anthraquinone present in fungal metabolites and constituent of rhubarb. 2-Hydroxyemodin proves to be mutagenic to Salmonella typhimurium TA1537 in the absence of activation system.
    2-Hydroxyemodin
  • HY-N6683
    15-Acetyl-deoxynivalenol
    		99.15%
    15-Acetyl-deoxynivalenol is a highly toxic trichothecene found in cereals, and a metabolite of deoxynivalenol, exhibits toxicity to HepG2 cells.
    15-Acetyl-deoxynivalenol
  • HY-136612
    DCBA
    		99.65%
    DCBA is a metabolite of insect repellent N-N-diethyl-meta-toluamide (DEET). The concentration of DCBA in urine can assess exposure to DEET.
    DCBA
  • HY-132995
    DP-1
    		99.66%
    DP-1, a degradation product of SDC-TRAP-0063, is a fragment of Ganetespib. Ganetespib is a heat shock protein 90 (HSP90) inhibitor with anti-tumor activity.
    DP-1
  • HY-101108
    Tazarotenic acid
    		99.57%
    Tazarotenic acid is the metabolite of Tazarotene. Tazarotenic acid binding to retinoic acid receptors (RARs) is the probable molecular target of retinoid action. Tazarotenic acid has the potential for the research of warty dyskeratoma.
    Tazarotenic acid
  • HY-Y0469
    1-Aminohydantoin hydrochloride
    		≥98.0%
    1-Aminohydantoin hydrochloride is a major metabolite of nitrofurantoin in animal tissues and can be used as a standard for the determination of residues of veterinary agents in meat, milk et.al. 1-Aminohydantoin hydrochloride covalently binds to tissue proteins and is released from the tissues under slightly acidic conditions and derivatized with 2-nitrobenzaldehyde to form nitrophenyl derivatives of AHD before detection.
    1-Aminohydantoin hydrochloride
  • HY-116016A
    Etilevodopa hydrochloride
    		99.40%
    Etilevodopa (L-Dopa ethyl ester) hydrochloride, an ethyl-ester proagent of Levodopa, is rapidly hydrolyzed to Levodopa and ethanol by nonspecific esterases in the gastrointestinal tract. Etilevodopa hydrochloride is used for the treatment of Parkinson disease (PD). Levodopa is the direct precursor of dopamine and is a suitable proagent as it facilitates CNS penetration and delivers dopamine.
    Etilevodopa hydrochloride
  • HY-A0058
    Retinyl glucoside
    Retinyl-β-D-glucoside is a naturally occurring and biologically active metabolites of vitamin A, which are found in fish and mammals.
    Retinyl glucoside
  • HY-135384
    tert-Buthyl Pitavastatin
    		98.46%
    tert-Buthyl Pitavastatin is the  metabolite of Pitavastatin. Pitavastatin is a potent HMG-CoA reductase inhibitor.
    tert-Buthyl Pitavastatin
  • HY-135389
    Desmethyl Levofloxacin
    		99.77%
    Desmethyl Levofloxacin is a metabolite of Levofloxacin. Levofloxacin, a synthetic fluoroquinolone, is an antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
    Desmethyl Levofloxacin
  • HY-B1787
    Sulindac sulfone
    		98.08%
    Sulindac sulfone is an mTORC1 pathway inhibitor and a metabolite of Sulindac. Sulindac sulfone inhibits colon cancer cell growth and induces cell cycle arrest. Sulindac sulfone is used in cancer research.
    Sulindac sulfone
  • HY-128696
    Amlodipine aspartic acid impurity
    		99.23%
    Amlodipine aspartic acid impurity is the impurity of Amlodipine aspartic acid. Amlodipine aspartic acid is a calcium channel blocker with antihypertensive and antianginal properties.
    Amlodipine aspartic acid impurity
  • HY-B1417S
    Nortriptyline-d3 hydrochloride
    		99.75%
    Nortriptyline-d3 (hydrochloride) is the deuterium labeled Nortriptyline hydrochloride. Nortriptyline hydrochloride (Desmethylamitriptyline hydrochloride) is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and used to relieve the symptoms of depression[1].
    Nortriptyline-d<sub>3</sub> hydrochloride
  • HY-133813A
    Apovincaminic acid hydrochloride salt
    		≥98.0%
    Apovincaminic acid hydrochloride salt is an orally active and brain-penetrant main active metabolite of Vinpocetine (VP). Apovincaminic acid hydrochloride salt exerts a neuroprotective type of action.
    Apovincaminic acid hydrochloride salt
Cat. No. Product Name / Synonyms Application Reactivity